Zolmitriptan Tablets

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Zolmitriptan is a generic medication used to treat migraines and is highly effective in providing fast symptom relief. Zolmitriptan is available as a 2.5mg tablet, which may be swallowed whole with water. The branded version of this medication is known as Zomig.

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    What is Zolmitriptan?

    Zolmitriptan is a 5HT1 receptor antagonist used in some patients who suffer from a clear diagnosis of migraine attacks that do not respond adequately to analgesic medications. The branded version of this medication is called Zomig.

    How does Zolmitriptan work?

    Zolmitriptan is used to treat an acute migraine attack (with or without an aura), through acting on 5HT1 receptors in the brain to help deal with factors that contribute towards the development of a migraine attack such as blood flow and trigeminal nerve activity.

    How do I use Zolmitriptan?

    Zolmitriptan should be taken at a dose of 2.5mg repeated after 2 hours if migraine recurs (however 5mg can be taken for subsequent attacks in patients not achieving satisfactory relief with the 2.5mg dose). It is advisable to be taken as early as possible at the onset of an attack. If you do not respond to the first dose, it is unlikely that the second dose will be beneficial for treating the same attack. No more than 10mg or two doses should be taken in a 24-hour period.

    What are the cautions related to Zolmitriptan use?

    Although Zolmitriptan is a commonly prescribed medication in the UK but it may not be suitable for everyone. This medication should not be used by people suffering from certain conditions and those taking particular medications.

    You should always read the patient information leaflet (PIL) for Zolmitriptan before taking this medication to ensure it is safe for you to use.

    What are the side effects of Zolmitriptan?

    Zolmitriptan like all medications can be associated with certain side effects although not all patients would experience these.

    Common Side Effects of Zolmitriptan include:

    • Drowsiness or dizziness, which may affect the performance of skilled tasks (e.g. driving)
    • Feeling sleepy
    • Headache
    • Feeling or being sick
    • Abnormal sensations in the fingers and toes
    • Dry mouth
    • Difficulty swallowing
    • Muscle weakness or muscle pain

    For more information about the side effects associated with this medication see the patient information leaflet or contact PostMyMeds.

    What alternatives are available?

    There are many different 5HT1-receptor agonists (Triptans) used to treat migraine attacks, including Sumatriptan (Imigran), Rizaptriptan (Maxalt) and Zolmitriptan (Zomig).

    These medications are also available in various formulations such as nasal sprays, oral wafers and orodispersible tabets. If you do not respond to one, an alternate 5HT1-receptor agonist or formulation may be used.

    Where can I find more information on Migraines & Zolmitriptan?

    Please refer to the patient information leaflet (PIL) for more information on Zolmitriptan. You can find more information on Migraines on the following page.

Although all of our content is written and reviewed by healthcare professionals, it should not be substituted for or used as medical advice. If you have any questions about your health, please speak to your doctor.

Authored Dec 02, 2015 by Joseph Issac, MPharm
Reviewed Sep 28, 2021 by Prabjeet Saundh, MPharm