Epiduo Gel
Epiduo Gel

Epiduo 0.1%/2.5% Gel (45g)

From: £31.99

Epiduo gel is a topical prescription treatment containing adapalene and benzoyl peroxide, which work together to unblock pores and attack bacteria that cause acne.

You can view the prices of this treatment using the menu below and it is available through our service with free discreet delivery straight to your doorstep.

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    What is Epiduo?

    Epiduo is a gel used to treat acne vulgaris when comedones, papules and pustules are present. Epiduo is the brand name of this medicine and it is dual acting containing two active ingredients; adapalene and benzoyl peroxide. Adapalene is a retinoid, whereas benzoyl peroxide is an antimicrobial agent and they both work in different ways to treat acne.

    Adapalene is a retinoid and helps reduce inflammation and the formation of whiteheads and blackheads on the outer layer of the skin and is known as an advanced third generation retinoid which is often better tolerated than previous generations. Adapalene works specifically on the skin processed that cause acne. Benzoyl peroxide as an antimicrobial agent works by attacking and killing bacteria on the skin. It also softens and peels the outer layer of the skin, helping bread down whiteheads and blackheads.

    How do you apply Epiduo?

    Epiduo is normally applied once day, in the evening. You should apply a thin layer over the entire acne affected area. You should wash your hands thoroughly before and after use and apply the treatment to a clean, dry skin using your fingertips. It should not be applied near or to the eyes, lips and other sensitive areas. It should not be applied to damaged skin, broken skin, skin with eczema or sunburnt skin. This medicine is for external use only.

    How do you buy Epiduo?

    Epiduo is a prescription only treatment so it cannot be purchased over the counter at your pharmacy. It may be available from your GP or a suitable healthcare professional. We do offer Epiduo through our service and you would just need to fill in a free consultation online for it to be reviewed by our prescribers so we can advise if it is safe and suitable for use.

    How effective is Epiduo?

    All acne treatments applied to your skin can take a while for visible results and you may need to wait up to 8 weeks to begin seeing a difference. It is important to be consistent with your use of this treatment for it to be effective. Because of the way the two active ingredients in Epiduo work, not only does the gel helps manage the appearance of acne, it also helps prevent future outbreaks.


    Epiduo is not suitable for those with hypersensitivity or allergy to any of its ingredients.

    It should not be used if you are pregnant or planning a pregnancy.

    Women who are sexually active should only use this treatment if they are using effective contraception (oral progestogen-only contraceptives are not considered effective).

    You should avoid exposure to strong sunlight and UV lamps whilst using this medicine and you should not use sunbeds.

    If sun exposure is unavailable, an appropriate sunscreen or protective clothing should be used.

    If you experience sensitivity or irritation when using this treatment, stop using it and inform your doctor.

    Side effects

    Like all medicines, this treatment can cause certain side effects although not everybody will experience them. Common side effects include:

    • Irritation of the skin
    • Burning sensation
    • Dry skin
    • Local skin rash
    • Redness
    • Scaling

    Certain side effects may become worse during the first week of use and then tend to settle. If irritation occurs, you may be advised to use non-comedongenic moisturizers, to use the medication less frequently, to suspend the use temporarily or to completely stop using it.

    If you get any side effects, please speak to your doctor or pharmacist.

    You can view more information regarding the side effects of Epiduo medicine in the patient information leaflet.

    Can I use Epiduo with other medication?

    Epiduo should not be used with other topical acne treatments, specially those that contain retinoids or benzoyl peroxide. You should also be cautious when using certain cosmetic products with this treatment, especially if irritating, drying or exfoliating effects are used. You should always check with your doctor to ensure any medication you are taking does not interact with Epiduo gel.

    Can Epiduo Gel cause staining?

    Epiduo should not come into contact with any colour material such as hair and dyed fabrics. This is as it may result in bleaching and discoloration.

    Can Epiduo be used during breastfeeding?

    Epiduo may be used during breastfeeding but this should be discussed with your doctor. You should ensure infants do not come into contact with treated areas such as the chest.

    How do you store Epiduo 0.1%/2.5% Gel?

    This medicine should be kept out of the sight and reach of children.

    It should not be used after the expiry date, which is stated on the tube and carton. The expiry date refers to the last day of that month.

    Discard the tube or pump 6 months after opening.

    Do not store above 25°C.

    Where can I find more information on Epiduo (adapalene and benzoyl peroxide) Gel?

    You can view more information about this medicine in the patient information leaflet.

Although all of our content is written and reviewed by healthcare professionals, it should not be substituted for or used as medical advice. If you have any questions about your health, please speak to your doctor.

Authored Jun 04, 2021 by Joseph Issac, MPharm
Reviewed Sep 08, 2021 by Prabjeet Saundh, MPharm