Differin cream
Differin Gel
Differin cream
Differin Gel

Differin 0.1% Cream/Gel

From: £29.99

Differin contains the active ingredient adapalene. It is available as a Differin Cream and Differin Gel and is used in mild to moderate acne.

You can view the prices of both the cream and gel using the menu below and it is available through our service with free discreet delivery straight to your doorstep.

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    What is Differin?

    Differin is a gel or cream used to treat mild to moderate acne vulgaris, containing an adapalene in a 0.1% concentration. Adapalene is a retinoid and helps reduce inflammation and the formation of whiteheads and blackheads on the outer layer of the skin. Retinoids are a group of medication, however adapalene is a third-generation retinoid and has many of the same effects as previous generations retinoids like tretinoin but is often better tolerated.

    How do you apply Differin?

    Differin is normally applied once day, in the evening. You should apply a thin layer over the acne affected area. You should wash your hands thoroughly before and after use and apply the treatment to a clean, dry skin using your fingertips. It should not be applied near or to the eyes, lips and other sensitive areas and should not be applied to broken skin. This medicine is for external use only.

    How do you buy Differin?

    As Differin is a prescription only mediation, it cannot be purchased over the counter at your pharmacy. It may be available from your GP or a suitable healthcare professional. We do offer Differin through our service and you would just need to fill in a free consultation online for it to be reviewed by our prescribers so we can advise if it is safe and suitable for use.

    How effective is Differin?

    All acne treatments applied to your skin can take a while for visible results and you may not see results for up to eight weeks. However, it is important to be consistent with your use of this treatment for it to be effective.


    Differin is not suitable for those with hypersensitivity or allergy to any of its ingredients.

    It should not be used if you are pregnant or are planning a pregnancy.

    Women who are sexually active should only use this treatment if they are using effective contraception.

    You should avoid exposure to strong sunlight and UV lamps whilst using this medicine.

    If sun exposure is unavailable, an appropriate sunscreen or protective clothing should be used.

    If you experience sensitivity or irritation when using this treatment, stop using it and inform your doctor.

    Side effects

    Like all medicines, this treatment can cause certain side effects although not everybody will experience them. Common side effects include:

    • Dry skin
    • Irritation of the skin
    • Burning sensation of the skin
    • Redness of the skin

    You can view more information regarding the side effects of Differin cream in the patient information leaflet.

    If you get any side effects, please speak to your doctor or pharmacist.

    How do you store Differin?

    This medicine should be kept out of the sight and reach of children.

    It should not be used after the expiry date, which is stated on the tube and carton. The expiry date refers to the last day of that month.

    Keep the medicine in its original container. Do not store above 25°C and do not freeze.

    Can Differin be used during breast feeding?

    The amount of Differin in milk is probably too small to be harmful but you should ensure infants do not come into contact with treated areas.

    Where can I find more information on Differin (adapalene) cream?

    You can view more information about this medicine in the patient information leaflet

Although all of our content is written and reviewed by healthcare professionals, it should not be substituted for or used as medical advice. If you have any questions about your health, please speak to your doctor.

Authored Jun 04, 2021 by Joseph Issac, MPharm
Reviewed Sep 08, 2021 by Prabjeet Saundh, MPharm