Differin cream
Differin Gel
Differin cream
Differin Gel


From: £29.99

Differin is an effective treatment for mild to moderate acne in teenagers and adults. It contains a third-generation retinoid to fight the build-up of dead skin cells that causes blackheads, whiteheads, and pimples. This prescription strength treatment is available to buy online in a cream or gel from Post My Meds. Order today for quick delivery, and to protect your privacy, we guarantee your order will arrive in discreet packaging.

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    Differin cream/gel contains the active ingredient adapalene (0.1%) – a powerful third-generation retinoid that improves skin turnover (exfoliation). It works by getting rid of the dead skin cells that can clog your pores and cause painful breakouts of spots.

    By reducing inflammation, adapalene improves the appearance of the skin. It calms and soothes red, irritated patches, and enhances the overall skin tone and texture.

    This topical cream/gel is effective at treating acne on the face, chest, and back. After 12 weeks of using Differin, most people notice a significant improvement in their acne.

    How to use Differin adapalene

    Differin is a topical product that should be applied once every day in the evening. Apply a thin layer over the affected area using your fingertips, and follow these guidelines:

    • Make sure the area is clean and dry before you apply the cream/gel
    • Do not use near your eyes, lips, or other sensitive areas
    • Do not use on broken skin
    • Don’t forget to wash your hands before and after

    Before you start treatment, you should always read the patient information leaflet.

    Differin gels or creams can cause side effects in some people. The most common are:

    • Dry skin
    • Irritation of the skin
    • A burning sensation
    • Redness of the skin

    It is normal to experience some irritation within the first four weeks of using Differin while your skin adjusts. However, if your symptoms get significantly worse or they don’t improve after four weeks, stop the treatment and make an appointment to see your GP.

    In very rare cases, Differin can cause an allergic reaction. If you experience a rash, hives, itching, dizziness, or swelling of the face, lips, or throat that makes it difficult to swallow or breathe, you should seek immediate medical help.

    This type of acne treatment is not suitable for everyone – your doctor or pharmacist will ask about your medical history and any other medicines you are currently taking before they prescribe Differin. Specifically, you should not use this topical treatment if you are pregnant, or planning to be, or if you are allergic to any of its ingredients.

    Adapalene gel (Differin) can cause sensitivity to light so while you are using it, you should avoid artificial UV light and strong sunlight. Where this is not possible, use plenty of sunscreen and wear protective clothing.

    For a full list of side effects and cautions, download the patient information leaflet.

    Can I breastfeed while using Differin?

    Differin is safe to use while breastfeeding. However, we recommend that you don’t use it on your chest where it might come into direct contact with your infant while feeding.

    Can I use Differin with other acne products?

    Other acne products containing benzoyl peroxide, clindamycin, and erythromycin can be used alongside Differin, but they should be applied at a different time. We would recommend using the treatments in line with the advice provided by your GP.

    Can you buy Differin gel over the counter?

    Differin is a prescription-only medication, so it can not be purchased over the counter in the UK. Before you can buy it from us, you must complete an online consultation. Your answers will be reviewed by our pharmacy team who will check to make sure that it is safe for you to use this treatment. The form is quick and simple to complete, and everything you tell us is kept in the strictest confidence.

    How long does it take for Differin to work?

    Everyone responds differently to topical acne treatments. It can take up to eight weeks to notice a difference, but in some people, it can be closer to 12 weeks.

    During the first four weeks, you might notice that your skin is red and irritated – this is known as retinization. It’s simply your skin adapting to the retinoids contained in Differin. Though third-generation retinoids are much better tolerated than their predecessors, it can take a while for your skin to get used to this active ingredient.

    If you haven’t noticed a difference after three months of using Differin, make an appointment with your GP to discuss other treatment options.

    What is the difference between Differin cream and gel?

    Differin cream and gel both contain the same active ingredient – 0.1% adapalene. However, the gel is more suited to oily skin and the cream is considered better for sensitive skin and may cause less irritation in some people.

    Is it safe to buy Differin gel UK from an online pharmacy?

    Online pharmacies are governed by the same rules as high-street pharmacies. We are registered with the General Pharmaceutical Council and everything we sell is approved by the UK medicines regulator (MHRA), so you can rest assured that you are in safe hands with Post My Meds.

    If you want to know more about Differin and how it works, read our frequently asked questions. You can also download the patient information leaflet, which is full of practical advice or get in touch with the friendly team at Post My Meds.

Although all of our content is written and reviewed by healthcare professionals, it should not be substituted for or used as medical advice. If you have any questions about your health, please speak to your doctor.

Authored Jun 04, 2021 by Joseph Issac, MPharm
Reviewed Jun 30, 2022 by Prabjeet Saundh, MPharm